Hi 👋🏾 I’m Namrata, founder of ⚛️⚛️⚛️ Diffuse Bio! ⚛️⚛️⚛️
At Diffuse, we computationally design therapeutics, vaccines, and enzymes better, faster, and cheaper — but most importantly, we generate molecules that simply can’t be designed with existing methods today.
Proteins are macromolecules that mediate a significant fraction of the cellular processes that underlie life. An important task in bioengineering is designing proteins with specific 3D structures and chemical properties which enable targeted functions.
So far, computational protein design methods have had some success — but have enormous limitations, the primary one being low success in downstream validation experiments. These methods are also painfully slow and scale poorly.
For the past several years, I’ve been working on re-envisioning the computational protein design toolkit with AI in my PhD and beyond, with the goal of overcoming these challenges. Some highlights are the first crystal structures of AI-designed proteins (i.e. experimental validation) and the first diffusion models for protein structure and sequence generation. Below you can see one of our early models producing structures unconditionally from noise!
Now, we’re scaling up these methods and applying them to grand challenge problems in molecular design. We’re able to handle a whole array of protein engineering tasks at the push of a button — from loop redesign and sequence engineering, all the way to binder design and de novo structure generation.
Check out our coverage in the New York Times and NBC news, and get in touch at info@diffuse.bio!