Epinoma

We engineer proteins that control the operating system of biology.

Diagnostics Scientist (Ph.D. Required) at Epinoma

$90k - $125k
Location
San Carlos, California
Job Type
Full-time
Experience
1+ years
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Varun Govil
Varun Govil
Founder

About the role

Responsibilities

  • Develop diagnostic methods to detect epigenetic signatures on circulating tumor DNA in human plasma samples
  • Lead and execute process development to optimize cell growth, transfection, and viral infection using shake flasks, small-scale, and large-scale bioreactors.
  • Engineer recombinant proteins able to detect specific DNA modifications
  • Conduct head-to-head comparative experiments against commercial products
  • Lead QC efforts for protein purification and assay development
  • Provide support for and lead the transfer of developed upstream processes to internal and external manufacturing parties
  • Author technical reports, SOPs, batch records and technology transfer documents; contribute to scientific documentation of patent applications and subsequent internal and external presentation and/or publication of new technologies
  • Support lab operations through management of lab equipment; support development of lab capabilities through analysis of lab operations and capital management. Lead acquisition of new lab equipment as needed including assessing requirements and developing proposals.
  • Train and oversee junior colleagues with respect to lab activities

Qualifications

  • Ph.D in protein engineering, molecular biology, bioinformatics, bioengineering, biochemistry, biotechnology, or related fields
  • Previous experience developing manufacturing processes in protein biologics
  • Previous experience with DNA-protein binding assay techniques
  • Previous experience with bacterial protein expression and purification using magnetic beads
  • Proficient with immunoprecipitation such as ChIP or ELISA
  • Strong desire to learn new techniques, willingness to work collaboratively as part of a team, and be productive in a fast-paced start-up environment

Recommended

  • Ph.D. with 0-2 years of industry or relevant experience in process development
  • Ph.D. with experience in clinical assay development and/or protein engineering strongly desired
  • Prior experience with protein modeling is strongly desired
  • Prior experience working with epigenetic modifications
  • Proficient with aseptic techniques and the use of shake flasks, rocking bag bioreactors, and stirred tank bioreactors at various scales
  • Knowledge of statistical design of experiments, as well as data analysis using JMP or other statistical package is desired

Why you should join Epinoma

Epinoma is pushing the boundaries of scientific excellence and protein engineering to make the world a healthier place to live. Our first customer will be the 50B market of blood test developers as our technology can improve their product performance. Longer term, we will build a second generation of epigenetic medicines that are safer and more effective for patients.