We make dendritic cells from a patients own stem cells and program them to cure diseases, starting with cancer.
Your immune system keeps you healthy. If it loses control, diseases like cancer, chronic infections, and autoimmunity can develop. We created a platform that enables us to produce a master regulator of the immune system (the dendritic cell) from patient stem cells. We program these cells so that they can make corrections to dysfunctional immune systems and bring disease back under control. We’re starting with cancer.
Prior to starting Guardian Bio, Ananya…
Prior to starting Guardian Bio, Ricky…
The overall problem is that the immune system unfortunately can’t always maintain control over disease. Cancer specifically actively suppresses the immune system. It has to. If the immune system maintains control, it will kill the cancer and disease will not develop.
One of the immune cell types often suppressed by cancer are dendritic cells, which sit at the helm of the immune system. Dendritic cells (DCs) direct and dictate immune responses. DCs are often deficient or dysfunctional in cancer patients, creating severe limitations in the body’s ability to fight off cancer, even when treatments like chemo and immunotherapy are applied.
We take stem cells from cancer patients, turn them into dendritic cells, program them against that patient’s tumor, and re-introduce them back into the body. This stimulates a diverse yet targeted and robust immune response against the cancer.
Our dendritic cell-based platform can be adapted to a variety of diseases. When we train DCs against different targets, our therapy can reignite immune responses against chronic infectious diseases or suppress immune cells triggering autoimmunity.
Our dendritic cell-based therapy is synergistic with many other immunotherapies including checkpoint inhibitors, peptide and mRNA-based cancer vaccines, oncolytic viruses, etc, potentially extending the reach of these therapies to patients who would not have responded before.