Our mission is to make biology easier to engineer.
The Biomolecule Purification and Characterization (BPC) team is composed of experienced protein and nucleic acid scientists and biochemists. We develop purification and characterization methods for a wide range of modalities (e.g. recombinant proteins, enzymes, AAVs, VLPs, RNA), from several different expression hosts (microbial, mammalian, fungal, etc.), to support cell engineering programs at Ginkgo. Our team operates at the intersection of protein and nucleic acid engineering, high-throughput screening, fermentation, and downstream processing to help purify and assess biomolecules that are central to the mission at Ginkgo. We utilize the latest software and automation to develop low, mid, and high throughput methods for protein and nucleic acid purification, enzyme kinetics and biophysical characterization.
We are looking for a highly skilled and motivated Sr.Scientist with expertise in RNA biology - specifically RNA purification and characterization. Your role at Ginkgo will require you to work collaboratively with scientists across different teams focused on designing, screening and purifying RNA constructs for therapeutic and non-therapeutic purposes. Your primary responsibility will be to develop methods for RNA purification (chromatography and non-chromatography based) and characterization of engineered RNA constructs (mRNA, circRNA, etc). Prior experience in large-scale RNA purification and production will be strongly favored. We also value prior experiences with in vitro or cell-based experiments for the purpose of engineering RNA with durable, tissue-specific expression. Additionally, you will also have the opportunity to work on the purification and characterization of other biomolecules such as proteins, enzymes, AAVs, VLPs, etc.
Specific Role Description
Your primary responsibility is to perform hands-on development of purification and characterization methods for nucleic acids such as mRNA and circRNA, with the ultimate goal of generating therapeutic grade material for in-vitro downstream assays and pre-clinical in-vivo studies.
Preferred Capabilities and Experience
Ginkgo Bioworks is the organism company. We design custom organisms for customers across multiple markets. We build our foundries to scale the process of organism engineering using software and hardware automation. Organism engineers at Ginkgo learn from nature to develop new organisms that replace technology with biology.
Engineering biology isn't easy. It is frustratingly, painfully difficult. It's programming without a debugger, manufacturing without CAD, and construction without cranes. At Ginkgo we are building a team that can build debuggers, write CAD, and operate cranes. We are looking for the best engineers, scientists, and hackers.