Lead Investigator, Preclinical Development

PostEra is building a modern 21st-century biopharma. We're using our advances in machine learning to accelerate Medicinal Chemistry and bring more cures to patients. PostEra advances small molecule programs through partnerships with biopharma while also advancing its own internal pipeline. We've raised $26M from top investors and closed $1Bn in AI partnerships, signing multi-year agreements with Amgen, Pfizer, and the NIH. PostEra also launched and led the world's largest open-science drug discovery effort; COVID Moonshot.

At PostEra we embrace a low-hierarchy structure to foster efficient operations:

·       We believe time spent navigating complex hierarchies in organizations is better invested in the pursuit of groundbreaking technology and scientific discoveries.

·       Our organizational structure is intentionally minimalist, and we encourage mentoring, collaboration, and participation in conferences and continuing education, to support our team members' growth.

·       We promote a culture where individual achievement is celebrated through proportional compensation and internal recognition, including meaningful promotions.

·       Ultimately, our collective focus is delivering cures to patients which we believe needs a huge amount of cross-disciplinary collaboration, so we've fitted our organizational structure to serve that end.

What you would do

• Develop and execute preclinical studies (GLP and non-GLP) for inclusion in IND applications
• Select and manage contract research organizations (CROs) to support IND-enabling studies
• Build and oversee a network of consultants and CROs and CDMOs for CMC, toxicology, regulatory, formulation, and DMPK
• Collect, analyze, and interpret data generated from preclinical studies, providing insights and recommendations based on findings.
• Preparation of preclinical documentation to support regulatory submissions
• Proactively identifying potential risks associated with preclinical development activities and formulating appropriate risk-mitigating strategies to ensure project success

Experience and skills you should have

• 10+ years of experience leading pre-clinical development of small molecule programs in areas such as CMC, toxicology, regulatory, formulation, and DMPK
• Strong knowledge of pre-clinical drug development and FDA requirements
• Experience managing CRO partners

Bonus Experience and Skills

• Experience in reproductive medicine and women’s health

Visa Sponsorship : Not at this time

Hiring Manager : Alpha Lee

Visit us at postera.ai