Using protein coupling to cure autoimmune disorders.
Catena’s technology lets us attach any two proteins together using an enzyme -tyrosinase- and the native amino acids tyrosine and cysteine within target proteins. It is a true platform technology because it enables the joining of any two soluble proteins together with minimal engineering and without restrictions due to protein size or complexity. Our work has already been used to modify cancer specific antibodies, but the most exciting application is in the emerging field of immune tolerance induction. Catena’s technology allows us to couple receptor binding proteins to immune triggering partners, letting us retrain the immune system when it targets healthy proteins. Such treatments could effectively cure autoimmune diseases such as Multiple Sclerosis, Graves' Disease and Hashimoto's by limiting inflammation towards ankyrin, anoctamin, and other self-antigens.