Machine Learning Startups funded by Y Combinator (YC) in New York 2026

May 2026

Browse 28 of the top Machine Learning startups funded by Y Combinator. Headquartered in New York, these are some of the hottest and fastest-growing startups. This doesn't include all companies originally founded in New York or by founders from there.

We also have a Startup Directory where you can search through over 5,000 companies.

  • Amika
    Amika
    Y Combinator LogoF2025
    Active • 2 employees • New York, NY, USA
    Amika is infra to build your software factory. We give your team sandboxed AI coding agents in the cloud: the same infrastructure Ramp, Coinbase, and Stripe built in-house. Kick off work from a web UI, CLI, Slack, or API. Use your preferred coding agent (Claude Code, Codex, etc.). Each agent understands your codebase, runs autonomously, and ships real PRs with live previews of the apps it changed. Use it as your daily driver or plug it into your own code-gen pipeline via API.
    artificial-intelligence
    infrastructure
    machine-learning
    b2b
  • Bezel
    Bezel
    Y Combinator LogoW2025
    Active • 1 employees • New York, NY, USA
    Bezel helps fashion brands create virtual photo/video shoots with AI. Upload images of clothes, select the human you want to model it, and Bezel generates pictures and videos that rival a full studio production. Every detail of the clothing is rendered flawlessly. Try it for yourself.
    machine-learning
    generative-ai
    marketing
  • Spotlight Realty
    Spotlight Realty
    Y Combinator LogoS2025
    Active • 4 employees • New York, NY, USA
    We are a full-service sell-side residential brokerage that lists and markets your properties. We also screen and schedule tenants showings with our AI agent for a third of the normal commission.
    real-estate
    machine-learning
  • Photonium
    Photonium
    Y Combinator LogoP2025
    Active • 3 employees • New York City
    Photonium is building software to automate optical system design. We supercharge optics experts with intelligent tooling to reduce costs and deliver faster. We handle the full design stack — from optimization, verification, sourcing, to prototyping — for AR/VR, quantum, biotech, metrology/chip fab, LiDAR, and more.
    hardware
    hard-tech
    manufacturing
    machine-learning
    b2b
  • Matcha
    Matcha
    Y Combinator LogoF2024
    Active • 2 employees • New York, NY, USA
    We're building Matcha, the faster, smarter way to hire clinical talent—helping hospitals find active, qualified candidates at a fraction of the time and cost of job boards or headhunters. Matcha engages candidates at scale, matching them to your organization by qualifications and cultural fit. Recruiters save time, hospitals save money, and candidates get a better experience—a radically better hiring model for everyone involved.
    machine-learning
    healthcare
    ai
    marketplace
    recruiting
  • FINNY AI
    FINNY AI
    Y Combinator LogoS2024
    Active • 28 employees • New York, NY, USA
    FINNY is the AI-native organic growth engine for financial advisors, focused on helping them grow their practices Our goal is to empower financial advisors to reach the right potential clients at the right time, with the right message. We are building a world where anyone who wants financial advice can connect with the right advisor, while helping advisors ensure organic growth, the most existential problem advisors face. The organic growth process has historically been highly inefficient and full of noise. Advisors often waste 60+ hours of business development to convert 1 new client. At FINNY, we are certain we can do better with AI. With our tool, advisors can: - Identify prospects within their target niche, aggregating thousands of data points per lead - Prioritize prospects based on their predicted likelihood of converting using F-Score, a score unique to each advisor and prospect pair - Automate the outreach and meeting scheduling with their high priority prospects In essence, FINNY does all the rote work for the advisors, letting them focus on what actually matters: the client relationship.
    fintech
    sales-enablement
    machine-learning
    finance
    automation
  • Ryse
    Ryse
    Y Combinator LogoW2024
    Active • 13 employees • New York, NY, USA
    Ryse is the only marketplace where investors who want to buy leases can trade with real estate operators who want to sell leases.
    fintech
    b2b
    machine-learning
    proptech
    marketplace
  • Ellipsis
    Ellipsis
    Y Combinator LogoW2024
    Active • 2 employees • New York City
    Ellipsis will help your team merge code 13% faster. Ellipsis is an AI developer tool that automatically reviews code and fixes bugs on pull requests. It uses LLM agents to catch logical errors, security issues, and can even enforce a team's style guide. The coolest part is that after Ellipsis identifies an issue, developers can tag @ellipsis-dev to have Ellipsis implement the fix. Internally, Ellipsis actually executes the code it generates, just like a human does. As a result, we allow developers to generate working, tested code directly from GitHub/GitLab.
    artificial-intelligence
    developer-tools
    ai
    machine-learning
  • Empirical Health
    Empirical Health
    Y Combinator LogoS2023
    Active • 4 employees • New York, NY, USA
    Don't die of heart disease. While heart disease is the #1 killer worldwide, 80% of heart disease is preventable. Empirical's program starts with an advanced lab test with 100+ biomarkers, including ApoB, Lp(a), inflammation, and more. Then, we help you model your lifetime risk of heart disease and generate a plan to reduce your risk to an optimal level. Then we help you achieve that plan. Empirical is licensed, registered, and insured to deliver real medical care in 30+ US states covering 200m+ people. We're growing >25% monthly.
    ai
    healthcare
    machine-learning
    generative-ai
    consumer-health-services
  • Guac
    Guac
    Y Combinator LogoS2023
    Active • 9 employees • Broadway, New York, NY, USA
    Guac accurately forecasts grocery demand to help supermarkets order and produce the right amount of inventory — reducing food waste and increasing availability.
    grocery
    machine-learning
    supply-chain
    climate
  • DataSuite
    DataSuite
    Y Combinator LogoW2023
    Active • 4 employees • New York, NY, USA
    DataSuite provides a way to manage and collect multi-terabyte multi-media datasets, and train generative models (diffusion, gan, interactive video) models based on them. We make it trivial for non-technical builders to create their own networks by providing an instant way to collect with AI without worrying about data formats, unzipping power, caching, or data locality.
    generative-ai
    machine-learning
    developer-tools
    devops
    artificial-intelligence
  • 222
    222
    Y Combinator LogoW2023
    Active • 16 employees • New York, NY, USA
    an IRL marketplace facilitating social experiences at local venues/events through AI recommendations.
    machine-learning
    marketplace
    consumer
    social
    artificial-intelligence
  • Coverage Cat
    Coverage Cat
    Y Combinator LogoS2022
    Active • 4 employees • New York, NY, USA
    Coverage Cat, the AI-native insurance broker, fixes your coverage limits and finds cheaper premiums. We provide both AI and human support so you can get fast answers on your policy and quickly get a response from a human agent so you can protect you assets or close on a new home. The AI-first approach drives core search, support and shopping experiences to ensure you get the best prices with the correct coverage.
    fintech
    insurance
    machine-learning
  • Toko
    Toko
    Y Combinator LogoW2022
    Active • 5 employees • New York, NY, USA
    Toko helps English learners in East Asia achieve speaking fluency. Through our mobile app, learners engage in short, realistic conversations with an AI and receive feedback on their grammar. With over 500 topics, learners can practice real-world scenarios ranging from small talk to workplace discussions. Toko offers a low-pressure environment to help learners build up their confidence. We make language fluency accessible to everyone - not just those with the means to meet 1:1 with a tutor. In Taiwan (our first market), Toko is ranked top 3 in the App Store for Education!
    ai-enhanced-learning
    education
    consumer
    generative-ai
    machine-learning
  • RedBrick AI
    RedBrick AI
    Y Combinator LogoW2022
    Active • 13 employees • Claymont, DE 19703, USA
    RedBrick AI's mission is to accelerate the adoption of artificial intelligence in radiology by building world-class software infrastructure. Currently, we are focused on helping radiology AI teams prepare high-quality datasets to train their algorithms. Radiology data, such as CT and X-ray scans, is an incredibly important source of truth in healthcare delivery. In fact, over 90% of all healthcare data is medical imagery! However, the global radiology workforce is overburdened. In the UK, for example, only 2% of radiology departments are able to fulfill their reporting requirements, and this trend is reflected worldwide. The acute state of radiology, coupled with the abundance of data, makes the use of AI in radiology a prime candidate. In 2022, $5.6 billion was invested in the development of AI in healthcare! However, a key hindrance to further adoption is the lack of sophisticated tools to build and deploy AI algorithms in clinical environments. This is the problem we’re focused on at RedBrick AI We're a team based out of Bangalore India, and USA. We're backed by leading institutional investors like Y Combinator and Peak XV (formerly Sequoia Capital India).
    healthcare
    aiops
    machine-learning
  • Cerebrium
    Cerebrium
    Y Combinator LogoW2022
    Active • 4 employees • New York, NY, USA
    Cerebrium is a serverless infrastructure platform for AI applications. We make it easier for companies to build and deploy AI based applications. We offer Serverless GPU's with low cold start times, over 12 varieties of GPU chips, allow you to run large scale batch jobs, run realtime voice applications and much more. We are used by the teams at Tavus, CivitAI, Twilio and many more.  Customers typically experience 40% in cost savings when compared to using traditional cloud providers and can scale models to more than 10K requests per minute with minimal engineering overhead.
    machine-learning
    infrastructure
    ai
  • Spade
    Spade
    Y Combinator LogoW2022
    Active • 25 employees • New York, NY, USA
    Spade is the next generation of fintech infrastructure. We’re building a financial data enrichment API purpose built to empower our customers to uncover the truth hidden within their transaction data. We use our vast, ground-truth merchant data set to decipher cryptic transactions, helping customers underwrite, detect fraud, build better banking infrastructure and get a unique understanding of their users’ spending habits.
    fintech
    machine-learning
    payments
    data-labeling
    ai
  • Axis
    Axis
    Y Combinator LogoW2022
    Active • 15 employees • New York, NY, USA
    Axis is a knowledge base of government regulations and officials that helps large companies do business in foreign markets. For example, if you want to operate in Saudi Arabia - our software tells you which laws you need to comply with and which officials you need approvals from. We currently cover major markets in Europe, Middle East, and Africa
    b2b
    subscriptions
    regtech
    machine-learning
  • Concord Materials
    Concord Materials
    Y Combinator LogoS2021
    Active • 7 employees • New York, NY, USA
    SaaS automation tools, financing and marketplace for bulk construction materials
    enterprise
    insurance
    fintech
    marketplace
    machine-learning
  • Roboflow
    Roboflow
    Y Combinator LogoS2020
    Active • 100 employees • New York, NY, USA
    Roboflow enables developers to make the world programmable. Use our tools to build better datasets (collect image, video / annotate), models (foundation and fine tuned small models), and deployments (self hosted, edge, APIs, SDKs) for computer vision. Over 250k developers, including those from over half the Fortune 100, build with our open source and hosted tools. Build with us: https://app.roboflow.com Hack with us: https://roboflow.slab.com/public/posts/roboflow-hackathons-external-u478m1iz Work with us: roboflow.com/careers
    computer-vision
    enterprise
    machine-learning
    developer-tools
    ai
  • Blue Onion
    Blue Onion
    Y Combinator LogoS2020
    Active • 27 employees • New York, NY, USA
    Blue Onion is the data backbone for tomorrow’s AI-powered finance teams — a subledger platform that transforms messy, scattered transactions into clean, reconciled, and automation-ready data.
    machine-learning
    finance
    ai
  • SPATE
    SPATE
    Y Combinator LogoS2018
    Active • 15 employees • New York, NY, USA
    Spate is your machine intelligence solution for finding the next big trend in Beauty and Food. For example, we spotted trends such as turmeric, face masks, and cold brew.
    machine-learning
    ai
  • Swayable
    Swayable
    Y Combinator LogoW2018
    Active • 30 employees • New York, NY, USA
    Swayable partners with the world's leading brands and advocacy groups to change minds, behaviors and attitudes. We are hiring in data science, full stack engineering, data visualization, design, and operations. We welcome unsolicited CVs from anyone, and especially encourage women and people from under-represented groups to talk to us.
    machine-learning
  • BitPatrol
    BitPatrol
    Y Combinator LogoP2025
    Acquired • 1 employees • New York, NY, USA
    Leverage cutting-edge AI to detect exposed credentials in real time and protect your organization from high-impact data breaches.
    machine-learning
    cybersecurity
    devsecops
  • PowerX
    PowerX
    Y Combinator LogoW2020
    Acquired • 20 employees • New York, NY, USA
    PowerX AI powered sensors create proprietary data to save corporations 30% or more in energy, water and emissions. 
    climate
    iot
    machine-learning
    energy
  • Pulpix
    Pulpix
    Y Combinator LogoW2016
    Acquired • 15 employees • New York, NY, USA
    Leveraging Artificial Intelligence to offer personalized video experience for online video platforms.
    artificial-intelligence
    video
    machine-learning
  • Yhat
    Y Combinator LogoW2015
    Acquired • 17 employees • Brooklyn, NY, USA
    Yhat (YC W15, pronounced y-hat) was an end-to-end data science platform. Acquired by Alteryx (NYSE:AYX)
    data-engineering
    machine-learning
    enterprise
    artificial-intelligence
  • Paperspace
    Paperspace
    Y Combinator LogoW2015
    Acquired • 50 employees • Brooklyn, NY, USA
    Paperspace is a cloud computing company creating simple and scalable accelerated computing applications. Our goal is to allow individuals and professional teams to seamlessly build and deploy computationally complex products and services. Paperspace is backed by leading investors including Y Combinator and Initialized Capital. Mission: Our mission is to make cloud computing more accessible through radical simplicity, community-driven technical resources, and straightforward pricing. -- To learn more about Paperspace, please visit https://www.paperspace.com/ or follow us on Twitter at: @hellopaperspace.
    machine-learning
    ai