Healthcare IT Startups funded by Y Combinator (YC) in the San Francisco Bay Area 2025

Kaigo Health provides an AI-powered outpatient care management platform that automates and scales remote care management for Medicare patients including post-discharge followups, ongoing check-ins, and monitoring. Using phone calls as an age-friendly interface, we aggregate patient responses, voice biomarkers, and remote patient monitoring data for powerful preventative and proactive healthcare.

LunaBill is building AI Voice callers for healthcare billing teams. Insurance claim follow-up calls account for the 80% of the daily workload of a healthcare billing team, with each call averaging 30 minutes. Since our launch in July we are now at $764K in contracted ARR, of which $428K is live revenue and the rest will go live by January 2026. Our customers see a 10x increase in claims followed up per biller in the first week and we have converted 100% of pilots to paying customers. We have automated 50,000+ calls and signed partnerships with top healthcare leaders like UC health systems, Mayo, Experian Health and more. The founders have known each other for over a year. Suhail is a 2x founder, with 3+ years of experience building in healthcare including operating a medical billing company with 200+ healthcare clients. David founded Skiesoft, Taiwan’s biggest healthcare AI scribe company, used by 120k+ healthcare professionals. He also worked as a data scientist at UCSF, building models to audit medical-coding accuracy. Yash was a researcher at various hospital systems including Mayo Clinic.

Pharmie is an AI assistant for pharmacies. It can pick up calls, process prescriptions, handle insurance follow-ups, and even help upsell specific drugs and services. Pharmacies can get 50+ phone calls a day, and missing phone calls means lost revenue from filling prescriptions. Pharmacy workflows are complex and custom to each pharmacy's needs. Generic tools are not enough, which is why AI agents can handle tasks end-to-end that previously could not be automated. We are constantly evolving Pharmie to become a suite of agents that supercharge your pharmacy. In the future, pharmacies will evolve into patient care centers, bridging the gaps in access caused by today’s overburdened healthcare system. Successful pharmacies will use AI to optimize their operations, resulting in a higher quality patient experience traditional pharmacies cannot match.

Phases uses AI to automate clinical trial operations, starting with patient recruitment. Our agent scans medical records and conducts human-like voice interviews to assess patient eligibility for clinical trials. Our vision is to run the entire clinical trial back-office with agents, getting drugs to market at a fraction of the time and cost it takes today.

Aegis is the all-in-one platform that helps healthcare providers recover lost revenue by automating insurance denial appeals—from intake to resolution. Built for billing teams, healthcare providers and hospitals.

Adentris is an AI compliance copilot for hospitals and clinics. We are like Grammarly for doctors, finding and fixing mistakes that lead to denied insurance claims or patient lawsuits. The industry today spends $40B doing this manually.

Paratus Health is the AI operations layer for outpatient clinics. We build autonomous agents that don’t just assist staff - they replace them, fully handling front desk calls, patient intake, insurance verification, documentation, and billing prep. Everything is deeply integrated into EHRs like Epic and Athena, eliminating the need for fragmented tools and manual work. No toggling between systems. No busywork. Just one intelligent system running your clinical operations - faster, smarter, and more profitably than ever before.

Harbera helps clinic keep their doctors credentialed and compliant. Our AI software continuously monitors and proactively helps admin teams re-credential doctors, preventing denied claims, disruptions in patient care, and lost revenue caused by doctors falling out-of-network.

Amby Health automates billing and quality reviews for ambulance agencies (EMS), replacing large back-office teams with AI. We analyze patient reports in seconds—not months—accurately coding claims and identifying liability and care risks while eliminating costly, error-prone manual processes.

We’re Toothy.ai. We’re building AI agents for dental practices that handle everything related to patient insurance. The average dental clinic spends over 160 hours a month on insurance tasks like verifying patient policies, billing, and claims processing. Our AI agents automate this entire workflow—including making insurance calls with voice AI—saving clinics time, reducing costs, and ensuring faster reimbursements.

Durate helps physician groups, clinics, and hospitals eliminate coverage gaps and create personalized schedules. Our platform auto-syncs with existing systems and uses smart automation to build optimized physician schedules in seconds.

The main document in a clinical trial is the study protocol. At large companies, floors of people use the protocol to create the study data collection forms, clinical database design, error checks, analysis code, and data transformation mappings. We use AI to automate the process of creating everything from the protocol, saving not only spend on headcount but also months of time which can translate to up to $27M in direct costs + lost revenue saved for a single phase 3 trial.

Syntra delivers an agentic medical billing platform that automates chart review, claim review, and claim entry with AI. Our specialty-specific AI agents understand the clinical and payer nuances needed to run your RCM function autonomously. Syntra powers hundreds of specialty practices nationwide and processes over $1B in medical claim charges every year.

Planbase has everything health clinics need to manage their team in one place: capacity planning, employee scheduling, credentialing and payroll.

Sage is a HIPAA compliant, AI-native communication platform that makes home care agency client-intake handling smarter, faster, and more reliable. Teams that use Sage can save over 100 minutes of busywork per prospect, freeing up their teams to manage a larger, faster growing business.

Pharos automates hospital quality reporting, saving millions in labour costs and helping to prevent avoidable patient harm. Today, clinicians spend thousands of hours manually pulling complex facts out of medical records for mandatory reporting and quality improvement. Our AI pulls those facts out of unstructured medical records automatically. We automate reporting and show staff where avoidable patient harm is happening.

Sample transforms healthcare operations from a burden into a competitive advantage. Our users build copilots in Sample to support processes like patient intake and reimbursement. These copilots don't just speed up work – they capture valuable ground-truth data that make our models smarter over time. We work with leading national providers, already have data from 76% of US oncology clinics, and our network is rapidly expanding across the nation.

All-in-one RTM platform designed for physical therapy and powered by AI

At Arini, we’re building the operating system for dental groups. Phones are the backbone of dental operations — 80% of appointments are still booked over the phone — yet practices miss 20–30% of inbound calls. That’s millions in lost revenue every month. Patient engagement is the biggest bottleneck to growth in dentistry, and we’ve built the most comprehensive AI-powered patient engagement suite in the industry. Arini manages calls, texts, and bookings. We’re going after a $220B, overlooked industry that still runs on legacy systems and outdated workflows. Arini is bringing AI to every part of the dental stack.

Penciled (W24) is an AI front office assistant for physical therapy. Penciled's AI assistant schedules out plans of care, sends reminders and processes last-minute cancellations, and fills openings with an automated waitlist. Penciled books thousands of appointments for physical therapists each month and integrates directly into EHRs like WebPT.

Andy is AI software that completes documentation for nurses doing home visits. Our software saves $8B a year; Tiantian was previously a PM at Google’s healthcare business and Max was a staff engineer on the health team at Apple. Andy benefits nurses and the agencies that employ them. Agencies that use Andy see up to 45% more detailed charts, 2x greater nurse productivity, and timely submission (no more billing delays!) With Andy, clinicians get their evenings back. Home health is the fastest growing segment of healthcare, doubling to $251B by 2031. Combined with recent nursing shortages and burnout, we’re seeing not just urgency, but excitement and joy, around adopting AI for home health.

At Verse Therapy, we're dedicated to making quality speech therapy accessible for everyone by empowering speech-language pathologists (SLPs) to launch and grow their own independent practices. We help therapists focus on what they do best—providing compassionate, personalized care—by taking care of the administrative tasks that often lead to burnout. Through thoughtful marketing and partnerships with care organizations like rehab centers, we connect SLPs with individuals who need their expertise. Our AI-enabled back office streamlines insurance processing, scheduling, and documentation, reducing non-therapy overhead. We're now live in 10 states with over 35 dedicated therapists and are in-network with leading insurance providers, making it easier for clients to receive the support they need.

Medical practices struggle with front desk shortages and nonstop admin work—ringing phones, scheduling mishaps, intake errors, and billing headaches. The result? Overworked staff and less time for patient care. Decoda Health’s AI platform takes over 80% of these tedious tasks, handling calls, scheduling, and payments while alerting staff only when necessary. By reducing chaos and streamlining operations, teams can focus on what truly matters—providing exceptional patient care.

We use generative AI to call insurance on behalf of healthcare clinics. We save clinics up to 40 hours of calls every week over existing outsourced human solutions. Compared to the existing solutions for benefits verifications: - We're faster -- by default, we have a turnaround of 24 hours compared to typically a 3 day turnaround for competitors - We can reach more payors -- as long as they have a phone line, we can support calling them for benefits. There's quite a few payors in both medical and dental (e.g. Seledent) that have yet to offer a digital retrieval of benefits - We're reliable and consistent -- there is no person-to-person variation or question skipping when it comes to working with software

At Latent, we're building medical language models to tackle the trillions of operational overhead weighing down healthcare. Our flagship product streamlines authorizations for life-saving drugs by analyzing EHR records and surfacing the most relevant data. We've built our product and signed enterprise contracts with some of the largest health systems in the US.

Preventing revenue leakage in health systems using AI

We empower clinicians with our AI platform for developing differential diagnoses and drafting clinical plans.

Entvin is building AI agents specifically designed to support regulatory teams in the life sciences industry. Our platform leverages AI to streamline workflows, automate complex tasks, and enhance efficiency throughout the regulatory process. By focusing on the unique needs of regulatory teams, we help companies navigate compliance, accelerate approvals, and reduce operational bottlenecks, all while ensuring data security and confidentiality.

Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.

We’re on a mission to leverage AI and voice technology to solve inefficiencies and revenue leakage in our healthcare system. With the rise of EHRs, the manual documentation burden on doctors has never been higher, leading to burnout and fatigue and high attrition rates. Assigning the correct diagnosis and billing codes is crucial for proper reimbursement and patient care, but medical coding is becoming more and more complex each year with growing numbers of codes (over 145,000 now), and doctors are unsupported by current technology to keep up with its ever increasing requirements. $125 billion is left on the table each year by healthcare organizations due to improper documentation and coding. Knowtex creates visit notes with up-to-date and accurate reimbursement codes from doctor-patient conversations, allowing the doctor to focus on patient care and preventing revenue leakage for hospital systems through standardized, transparent, and accurate documentation.

Delfino AI helps automate the repetitive phone calls that providers' offices make to payors

Metriport provides real-time access to comprehensive medical data for 300M+ individuals across the US. Our open-source intelligence platform helps organizations access, analyze, and exchange patient data while integrating with all major healthcare IT systems. If you’ve been to doctors in the US, you may have encountered the problem: how does a healthcare provider get access to your up-to-date medical history to treat you properly? Reliance on archaic methods is still the norm: typically, you or your provider need to call the facilities where you’ve previously received treatment (assuming you remember them all), just to have them send your records via fax (yep, fax). This can take weeks, only then to have a provider sift through hundreds of pages of unstructured docs, just to figure out basic things like your active medication list, what conditions you may have, latest lab results, etc. This not only delays care—it can cause improper treatment, since the medical history is critical for informing treatment decisions. Metriport integrates fragmented medical data from thousands of sources—including both national and state/regional Health Information Exchanges (HIEs), ADTs, EHRs, pharmacies, and labs—through a single API connector. The platform then standardizes, deduplicates, and enriches this data to create a comprehensive longitudinal patient record, with AI-powered clinical summaries. Along with a rich understanding of patient health history, healthcare providers also get realtime updates about their patients' health through Metriport. This includes getting notified when a patient is discharged from the hospital, picks up their prescription from the pharmacy, or has a new lab result available. Through this data, care teams get insights across their patient population, helping with 30-day readmissions prediction, care gap closure, risk adjustment, and more. On top of all of this, Metriport enables healthcare organizations to share net-new clinical information back to all major healthcare IT systems, and to become interoperable with popular EHR systems such as Epic, Cerner, athena, eClinicalWorks, and many more—forming an internet for healthcare data. Metriport improves both patient and provider lives at the point-of-care, supporting use cases such as medication adherence, transitions of care management, chart prep, and much more. If you want to do work that matters, get in touch with us today.

$1 T is spent today on back office tasks such as patient triaging, intake, eligibility checks, prior auths and claims. Specialized knowledge is required to complete these tasks making them prone to errors and bottlenecked by staffing. Lamar Health takes the burden off of providers and intelligently automates these tasks. Starting with specialty medications.

Our AI-powered healthcare information platform leverages LLMs to deliver accurate, up-to-date medical knowledge

Our mission is simple: challenge archaic rules and implied medical conventions in healthcare to better serve patients and physicians. Gradia is the backbone of the entire patient experience, helping patients get personalized, high-touch care while also making clinics more money. With our software patients can stay informed/educated about the status of their care, easily communicate with their providers, and get direct access to a specialized virtual care team. Our software is currently at several clinics across the Southeastern US and helping thousands of patients get the care they deserve. 

Osmind is the premier platform for clinicians and researchers advancing new life-saving mental health treatments. Today, mental health disorders are one of the leading causes of death worldwide, especially among young adults, and are tied to shortening lifespans. While there have been developments in new psychiatric medications since the first FDA approval in 1954, today there is a growing movement among clinicians, patients, and researchers who are recognizing the need to accelerate new science. The Osmind treatment platform is the first and only solution that solves specific challenges faced by neuropsychiatric clinics, spanning general psychiatry and interventional psychiatry (transcranial magnetic stimulation, ketamine, SPRAVATO®, psychedelic medicine, electroconvulsive therapy). The core electronic health record (EHR) technology is precisely developed for interventional treatment workflows and designed to support a strong therapeutic alliance, including journaling tools and assistance with health plan reimbursement, which is a significant access hurdle for millions of patients. Research from our platform is already helping to set new standards for mental health interventions. For example, in the largest published real-world analysis of ketamine infusion therapy for depression, we teamed up with Stanford University School of Medicine to share findings in the Journal of Affective Disorders (March 2022). We have multiple ongoing research studies leveraging our proprietary real-world data, including an even larger ketamine analysis leveraging machine learning to predict treatment outcomes. Osmind is a San Francisco–based public benefit corporation led by scientists, technologists, and psychiatrists. We are backed by top investors including DFJ Growth, General Catalyst, Future Ventures, Tiger Global, and Y Combinator.

We help healthcare companies run their practices. Eligibility, BI, claims, patient payments? Shoot us an email at founders@aperohealth.com Apero is a Y-Combinator-backed startup based in San Francisco bringing transparency and ease to medical billing. As one of the top startups from the Summer 2019 Y Combinator batch, we have raised from well-known investors including the creator of Gmail Paul Buchheit and the founders of Doctor on Demand, Gusto and Reddit, and serve startups that have raised over $1B in Venture Capital. The founding team are Stanford CS and Berkeley grads and include the CTO of Doctor on Demand having helped raised $240m and process millions of video calls. We are also hiring for engineers and product-minded operations people interested in giving price transparency to patients and providers. We serve practices nationwide, and integrate with leading EHRs as well.

MentalHappy is a secure and compliant platform that leverages AI and data-driven analytics to enhance the group-based therapy experience and boost client/patient engagement. Our platform streamlines administrative tasks for providers, improves group participant self-management capabilities, automates group participant check-ins, and identifies group members who may be at risk. Additional features on the platform allow providers to schedule and host virtual sessions, engage members in secure chat, and share health resources, and offer support groups

Blueberry Medical provides concierge pediatric care with at-home medical diagnostics and an always-available team of Pediatricians. Blueberry handles twice as may illnesses as any other telemedicine provider and has proven to reduce ER costs by 50%.

Out-of-pocket healthcare costs are skyrocketing and every day, people all across America are forced to make difficult decisions about their health. Lively is the benefits solutions provider that gets it right. We designed our solutions to take the guesswork out of managing benefits. And our innovative features are built to simplify benefits administration and evolve with your business. Managing wellness and wealth takes more than a series of transactions. By combining robust features with unparalleled service, we make benefits administration effortless, even when time and energy are limited. Experience benefits administration as it should be with Lively. Go to www.livelyme.com to learn about how HSAs other modern employee benefits can help you and your team.

About 50% of all out-of-pocket payments get never collected in U.S. healthcare. Collectly helps medical groups and practices accelerate and increase patient cash flow, decrease costs to collect, and increase patient satisfaction.

Healthcare is delivered by teams – nurses, doctors, and staff, specific to each hospital, clinic, and department. They want to do their best, but cannot keep up with constantly changing information. Burnout >50%. Unprecedented turnover. Growing medical errors (the #3 cause of death in the US). $100B+ in waste. Elemeno Health is a UCSF and Y Combinator-backed B2B SaaS for healthcare facilities– “a playbook in your pocket,” customized to support frontline teams with bite-sized training and communication at their fingertips, accessible 24/7 on any device. Our efficacy is demonstrated in our published results, passionate clients, and consistent renewals. 20x ROI. 75% decrease in medical errors.

Qventus’ mission is to simplify how healthcare operates so it just works — for everyone. The company offers an AI-based software platform that helps hospital teams make better operational decisions in real-time. Qventus addresses operational challenges across the hospital including emergency departments, perioperative areas, patient safety, in-patient, outpatient and pharmacy. Located in Silicon Valley, Qventus is honored to be working with leading public, academic and community hospitals across the United States. Founded in 2012, Qventus was named among Fast Company’s Most Innovative Companies for 2018. The company has also been recognized as a leader and innovator in operational excellence, with the 2016 Fierce Innovations Award in Healthcare and Healthcare Informatics 2017 Innovator Award. For more information about Qventus, please visit www.qventus.com

The Human Diagnosis Project (also referred to as “Human Dx” or “the Project”) is a worldwide effort to build an open medical intelligence system that maps the steps to help any patient. By combining collective intelligence with machine learning, Human Dx intends to enable more accurate, affordable, and accessible care for all

At AgileMD, we are building the most advanced real-time predictive analytics and clinical algorithms platform for hospitals. Our cloud-based engine helps thousands of doctors and nurses around the country make medical decisions, so that every patient receives the highest quality and value of care based on the latest medical knowledge and data.

The world’s No. 1 lab management platform. We help scientists easily organize orders, manage inventory, and save money.

Have you ever wondered why it's so hard for physicians to communicate quickly and why the leading cause of preventable death is still a delay in communication? Our team has built the solution for this. Medigram is a team of tier 1 health system CxO IT executives, technologists, SaaS exec, physicians, engineers, and data experts. We have developed a breakthrough service for the medical industry to save lives and for hospitals to make millions per year. Medigram instantly flags insights from clinician chats for immediate insight into hospital operations and patient care. This reduces critical response times by 50%. We've designed this system to provide instant, reliable messaging (including images and audio files) across very complicated network environments in hospitals. Medigram is secure, designed for HIPAA, and a full stack system which includes database back end, middleware, logic, and client apps for iOS, Android, desktop, and the web. Our solution to this is Mobile Intelligence For Healthcare by providing a secure, intelligent workflow management platform for the patient care ecosystem and medical professionals. Within the healthcare environment, you have physicians, the patient care team, EMR, workflow, data, and administration which needs to be tied together with intelligence through Medigram.