Healthcare Startups funded by Y Combinator (YC) in the San Francisco Bay Area that are currently hiring 2026

Juno is an AI personal health assistant for the 1B+ people living with chronic illness. Launched in October, Juno now supports 150,000+ patients globally.

BioStack is building the data engine for healthcare and drug discovery AI. The bottleneck is not models. It is access to high-quality biological data. Clinical and experimental data is fragmented, unstructured, and locked inside hospitals, labs, and CROs, while generating new data is slow and expensive. BioStack fixes this with proprietary clinical and preclinical data pipelines that turn real biomedical workflows into ML-ready training environments. We structure longitudinal multimodal data across imaging, EHR, and experimental assays, then package it for post-training and reinforcement learning so models can learn how research and care actually happen. Instead of static datasets, BioStack gives AI labs workflow-aligned data and environments that improve reasoning, decision-making, and real-world performance in biology and medicine.

Clara is an AI primary care and longevity practice from the team that founded and grew Circle Medical to $100M in revenue. Our mission at Clara is to add one billion years of healthspan to humanity. We do this with an AI with deep clinical knowledge, coupled with the ability to sift through medical data to detect trends and patterns that could be missed. Unlike Claude or ChatGPT, Clara can see your medical data and then act. Chat with Clara as you would a doctor and Clara can help with you make sense of symptoms, get medication refills, order and understand labs, and achieve health goals. Medical recommendations are preliminary until one of our human medical providers in the loop reviews and approves them.

We know how to improve cancer outcomes by 8x-10x: you catch it early. MRI is the most robust and powerful cancer-detection tool in the world, yet systems cost millions to purchase, take months to install, and require high levels of technical skill to operate. We've redesigned MRI from the ground up with new physics, algorithms, and hardware, all to bring cancer screening to the entire world. Our mobile MRI is an imaging clinic on wheels. No equipment to buy, no infrastructure needed. For a flat per-scan fee, any medical site can offer MRI cancer screening. Starting with prostate cancer. Then everything else.

Ruma Care automates all admin work for infusion clinics - starting with prior authorizations & copay assistance enrollment. Biologics are expensive medications that cost $80-$150K+ per year per patient, and often need to be administered in specific settings called infusion clinics. Medical providers buy these drugs up front to secure pricing deals and safer inventory - they are reimbursed for the cost of the medications through the patients’ insurance. Current medical workflows aren't built for infusion clinics. Inventory, storage, transport, and billing is still managed through paper and excel spreadsheets. And because they’re so expensive, these specialty medications are denied by insurers at a rate of 37% each year. When they are denied, when workflows fail, or patients are infused before paperwork is cleared, providers don’t get reimbursed for the medication and are left covering the costs. Ruma Care solves this so clinics get paid, patients get treated faster, and care teams spend less time fighting forms. We do this in three ways: 1. For each medication, diagnosis, and insurance combination, Ruma extracts the submission criteria required to get the drug approved by insurers. 2. We pull out the correct forms, then automate the form-filling for prior authorizations. 3. Lastly, we enroll patients in copay assistance programs, all in one workflow and platform. We turn a process that traditionally spans 70+ online portals, disparate paper forms, and manual phone calling into a single, streamlined platform. As we process prior authorizations, our models learn from denial patterns to understand exactly what insurers need to see to get a prior authorization approved.

What if you could train a biological foundation model on... the entire internet? Exonic is pioneering a new generation of biological foundation models, focused on heterogeneous, unstructured, and noisy datasets. Our first application is the design of safer gene therapies. In 2025, we used AI to set a new state of the art in liver cancer targeted gene therapy, validated in vitro in our lab in San Francisco. So far in 2026, we have trained a new model with unprecedented zero-shot generalization on genomic regulatory expression in hold-out biosample datasets. More to be shared soon.

Algen is using CRISPR to uncover disease-driving RNA messages to find treatments for cancer, inflammation and diseases with high unmet needs. We are harnessing the power of CRISPR and machine learning to find first-in-class drugs that modulate RNA messages at single-cell resolution. Algen's founders are bioengineer from Jennifer Doudna Lab and biotech commercialization expert, teamed up with experienced pharmaceutical executives.

Blank Bio is an applied AI research lab focused on increasing the success rates of clinical trials. We do this by training RNA foundation models that learn the patterns that shape disease progression and patient response to treatment. We aim to help pharma make more informed decisions in clinical trials by capturing the biology that makes each patient’s tumour unique. We’re a technical team of AI scientists and engineers from companies including Recursion, Deep Genomics, DeepMind, and Amazon, and institutions including Memorial Sloan Kettering Cancer Centre, Stanford, and the Vector Institute.

Novaflow is the AI data analyst for biology labs. -- Bioinformatics data analysis is a time-consuming and expensive process for scientists. With Novaflow, life scientists can upload experimental data, ask questions in plain English, and get instant, publication-ready plots, giving them results in minutes instead of months. Researchers at leading institutions like UCSF, Mount Sinai, UC Berkeley, and Harvard are already using Novaflow in their labs.

b12 makes high-value molecules that are otherwise hard to make. We help pharma companies plan and make new drugs, accelerating early-stage drug discovery from years to months. Andres built the first AI agent that can autonomously think and make molecules in a robotic lab, published in Nature Machine Intelligence (1000+ citations), and won the best paper award at the NeurIPS AI for Science conference. Zlatko is a 3x National Chemistry Olympiad champion, competed at IChO level, and medicinal chemist who has worked at Roche and leading lab robotics companies. Combined, we have an extensive network of hundreds of chemists, automation scientists, and AI 4 Science researchers. We run paid pilots with big pharma companies, demonstrating that our platform planned a set of experiments that achieved full conversion in a single attempt, eliminating the iteration cycle.

An AI-maximalist pharma platform. We use agents to buy drugs, run clinical trials, and sell for a profit. 10x faster and 20x leaner than incumbents. Sourcing Agent: Mines public/private databases and unstructured global data to surface overlooked preclinical candidates. Scientific Agent: Runs comp bio models (ESM-3, RFdiffusion, Boltz-2, AlphaFold) to assess safety and efficacy in silico. Commercial Agent: Analyzes FDA incentives, pricing dynamics, TAM, competitive landscape, and payer alignment. Clinical Agent: Runs digital twin simulations, evaluates CRO/CMC risk, and builds trial plans to Phase 1. PoS Agent: Evaluates the most critical factors that impact the likelihood of clinical trial success. Built by 2 Stanford CS students who have built 3 startups together before.

Pelica is the AI-native operating system for value-based care organizations. We unify claims, EHR, pharmacy, lab, and ADT data into one live record and put an AI copilot next to every team that depends on it: quality/Stars, pharmacy, care management, provider network, and risk adjustment. The copilots don't just surface insights. They do the work, from engaging members for preventative care using multi-channel communications to preparing provider field reps with everything they need before they walk in the door. So teams spend time on relationships, not admin.

Novoflow is building AI employees that automate medical operations for clinics. Novoflow built the universal bridge into EHR systems—so every workflow, from scheduling to billing, can finally run on AI. The first product is an AI employee that talks to patients and uses computer agents to book, reschedule, and recover cancelled appointments. Built for healthcare providers and hospitals.

The intelligence layer behind modern life sciences engagement, enabling compliant, continuous conversations across HCPs, patients, and field teams

We’re Toothy.ai. We’re building AI agents for dental practices that handle everything related to patient insurance. The average dental clinic spends over 160 hours a month on insurance tasks like verifying patient policies, billing, and claims processing. Our AI agents automate this entire workflow—including making insurance calls with voice AI—saving clinics time, reducing costs, and ensuring faster reimbursements.

10x helps dental practices turn missed revenue opportunities into booked appointments. We connect to a practice’s patient database, identify overdue recalls, lapsed patients, and unscheduled treatment plans, then use AI calling and texting to bring those patients back into the chair.

Avora helps dental groups (DSOs) boost case acceptance and institutionalize clinical excellence. We deploy agents that listen to appointments, identify coachable moments, and chart notes to save provider time.

Careforce builds AI Workers for healthcare orgs to take on coordination burden from staff and reduce time of care by autonomously identifying and outreaching patients (through phone, text, email, & mail) to schedule visits, book screenings, complete pre-post, and onboard. These agents require no integration, can navigate all tools, speak 29 languages, come with 50+ outreach scripts and have a remarkable 80% conversation-to-booking closing rate.

Ember is rebuilding the back office of healthcare finance. Behind every provider sits a mountain of administrative complexity, and that drag lands where it matters most: cost, capacity, and care. Ember clears it with intelligent automation, so provider groups can spend their time on patients, not paperwork. We're reimagining how revenue moves through healthcare, and how lean teams scale without trading away quality. Our platform drops into existing provider workflows, takes the manual work off their plate, and gives leaders real-time visibility into financial and operational performance. We're growing fast, and we're hiring sharp, resourceful people who want to build. Right now, that starts with you.

Syntra is a real-time medical AI audit platform for revenue, compliance, and care quality. In our first year post launch, Syntra has already audited over 1M patient encounters and over $200M in insurance collections, supporting hundreds of practice locations nationwide. Our customers start with Syntra’s chart and claim audit and build additional agents from there. Our agents learn each practice’s workflows, payer rules, and software stack on its own, enabling us to give every clinic in the country the operating efficiency they need to stay independent.

Planbase has everything health clinics need to manage their team in one place: capacity planning, employee scheduling, credentialing and payroll.

Dodo turns client communication into booked appointments, completed workflows, and predictive analytics, powering millions of client interactions annually for hundreds of clinics. Our multi-agent system autonomously runs scheduling, refills, intake, and follow-ups across calls and texts — integrating directly with clinic systems to cut communication overhead ~70% and act like a trained CSR 24/7.

Sage is a HIPAA compliant, AI-native communication platform that makes home care agency client-intake handling smarter, faster, and more reliable. Teams that use Sage can save over 100 minutes of busywork per prospect, freeing up their teams to manage a larger, faster growing business.

At Brighterway, we use AI to speed up the medical record review process in the Workers' Compensation Industry. Physicians and claims handlers spend hours reviewing thousands of pages of medical documents– our technology highlights the information that is most relevant to a doctor's specialty or a given injury, streamlining their review process and saving them time. Brighterway structures and deduplicates disorganized medical records (PDFs) and extracts the content that is medically relevant and related to a given claim, so they can focus on what matters most.

mdhub is the AI-native operating system for behavioral health. We combine AI workers with a purpose-built EHR, CRM, and RCM into one platform where clinical teams and AI collaborate across every workflow. Mid to large-sized behavioral health clinics run on disconnected legacy systems that weren't designed for today's demand. The result: clinician burnout, admin bloat, and patients waiting weeks for care. mdhub replaces the entire fragmented stack with a single AI-first platform. Our AI workers: Emma, AI Clinical Assistant: automates documentation and gives clinicians back hours every day. Sarah, AI Admissions Coordinator: handles 100% of inbound calls, verifies insurance, and books patients 24/7. Eric, AI Billing Agent: manages coding, claims submission, and denial management same-day. Our platform: mdhub EHR: the first clinical workspace built for AI from day one. Documentation, intake, treatment planning, e-prescribing, and billing in one place. mdhub CRM: every lead captured, every follow-up automated, nothing falls through the cracks. mdhub RCM: end-to-end revenue cycle management. From claim submission to collections, AI-powered and fully integrated. We're not another EHR with AI bolted on. We're not a point solution. We're the full operating system where AI workers and human teams run a clinic together. Hundreds of mid to large-sized behavioral health clinics use mdhub today, including some of the largest organizations in the country. One platform, less overhead, more patients seen.

Proteins power everything from the cells in your body to creating materials you rely on every day—but until now, we’ve been forced to discover their functions by trial and error. Designing a new therapeutic can take decades and billions of dollars, and even our best industrial catalysts work at a snail’s pace compared to their theoretical optimums. Anthrogen is changing that. By training massive AI foundation models on protein sequences and structures, we’ve unlocked the ability to generate—on demand—completely novel molecular machines with atomic-level precision. Simply describe the function you need, and our platform imagines the peptide or protein that will deliver it. We're building models to speed up billions of years of evolution into the span of an afternoon's worth of compute. The result? New-to-nature therapies, ultra-efficient catalysts for sustainable manufacturing, and a whole new frontier of molecular innovation—designed as precisely as any cutting-edge aircraft or microchip.

At Arini, we’re building the operating system for dental groups. Phones are the backbone of dental operations — 80% of appointments are still booked over the phone — yet practices miss 20–30% of inbound calls. That’s millions in lost revenue every month. Patient engagement is the biggest bottleneck to growth in dentistry, and we’ve built the most comprehensive AI-powered patient engagement suite in the industry. Arini manages calls, texts, and bookings. We’re going after a $220B, overlooked industry that still runs on legacy systems and outdated workflows. Arini is bringing AI to every part of the dental stack.

Scritch is building the leading AI systems for veterinary medicine, starting with voice agents that automate front-desk operations in veterinary practices.

Andy is AI software that completes documentation for nurses doing home visits. Our software saves $8B a year; Tiantian was previously a PM at Google’s healthcare business and Max was a staff engineer on the health team at Apple. Andy benefits nurses and the agencies that employ them. Agencies that use Andy see up to 45% more detailed charts, 2x greater nurse productivity, and timely submission (no more billing delays!) With Andy, clinicians get their evenings back. Home health is the fastest growing segment of healthcare, doubling to $251B by 2031. Combined with recent nursing shortages and burnout, we’re seeing not just urgency, but excitement and joy, around adopting AI for home health.

We're building the HaploHub: a SaaS platform for genetic testing labs, concierge medical practices, and payer/providers to: * predict disease risk for their patients based on proprietary or publicly available genetic models * securely host, manage, and interrogate the genetic data of their population * generate reports and run the most common inference algorithms (phasing, imputation, ibd, etc.) without writing code

TrueClaim is rebuilding health plan administration software from the ground-up, with modern technology and AI. Most health plans and third-party administrators (TPAs) still operate on outdated legacy technology that’s slow, error-prone and costly. We’re the modern alternative: AI-powered claims review, API-first architecture, and a platform that makes operating great health plans radically simpler. Think Shopify, but for health plans. We're on a mission to modernize how health plans operate to make the healthcare system more transparent, efficient and affordable for everyone.

Cair Health empowers billing companies, care management platforms, EHRs, offshore BPOs, provider groups, and specialty pharmacies with AI-driven RCM solutions. Our suite of AI Agents helps RCM teams streamline operations, reduce manual costs, and improve consistency—while maintaining full control over core workflows. Cair is trusted by 100+ practices across the country — including iconic VC-backed digital health startups, leading specialty EHRs, and some of the largest billing companies and BPOs Backed by Y Combinator, Foundation Capital, Soma Capital, Translink Capital & many others..

We use generative AI to call insurance on behalf of healthcare clinics. We save clinics up to 40 hours of calls every week over existing outsourced human solutions. Compared to the existing solutions for benefits verifications: - We're faster -- by default, we have a turnaround of 24 hours compared to typically a 3 day turnaround for competitors - We can reach more payors -- as long as they have a phone line, we can support calling them for benefits. There's quite a few payors in both medical and dental (e.g. Seledent) that have yet to offer a digital retrieval of benefits - We're reliable and consistent -- there is no person-to-person variation or question skipping when it comes to working with software

Quill Bills is a medical billing company that works with healthcare providers to significantly lower billing costs and recover denied claims. Our platform performs much of a biller's job autonomously, and we sell this platform to private practice doctors and medical MSOs.

Readily uses AI to free 20 million healthcare professionals from manual compliance work so they can focus on patient care. We've helped $B healthcare organizations cut regulatory analysis, policy drafting, and audit work by up to 90%, reducing consulting spend and compliance risk.

We're building autonomous robots to make surgery safe, easier and more efficient. Robots currently perform about 1/4 of surgeries but only help with the physical aspects. We use AI to make surgery cognitively easier. This has far greater potential to improve outcomes and reduce costs. Founded by 3x founders from medtech and autonomous vehicles, we're on track to be the fastest surgical robot to market of all time. First indication is prostate enucleation.

Auricle is a medical device company building a breakthrough neurostimulation implant to restore hearing in millions of patients who no longer benefit from hearing aids, get less than 60% on a word recognition test, but aren't prepared to make the jump to a cochlear implant. Our approach preserves remaining natural hearing through a reversible and less invasive surgery, addressing the key concerns that hold most patients back from getting a cochlear implant (currently the only treatment option for these patients). The company spun out of Stanford Biodesign having completed two acute human clinical studies demonstrating the approach will work. The team is now focused on developing their full implant system for their first clinical trial. Auricle addresses a currently unserved profile of hearing loss that affects a growing population of 3.5 million patients in the US and represents an immediately accessible $1.2B market opportunity with existing reimbursement.

Digital Clinics are facing an existential problem - fix margins, or die. We’ve built a clinic, and seen the tech they need to fix their margins. Now we’re bringing this tech back to other clinics. For our first customer, we’re projected to generate $2.5M in revenue.

At Latent, we're building medical language models to tackle the trillions of operational overhead weighing down healthcare. Our flagship product streamlines authorizations for life-saving drugs by analyzing EHR records and surfacing the most relevant data. We've built our product and signed enterprise contracts with some of the largest health systems in the US.

Kivo Health provides AI-powered virtual care for seniors with chronic disease, starting with lung disease. Kivo's AI powered virtual care programs help health plans reduce costs by keeping members healthy and out of the hospital.

Vitalize is solving the most pressing operations problems for health systems, starting with optimizing staffing and scheduling. We help hospitals dramatically reduce labor spend, improve operational efficiency, and unburden clinical leaders from hours of work per day. We're partnered with some of the country's most innovative health systems, and are excited to share more details soon!

Diffuse is building generative AI for protein design. Our mission is to build AI systems that engineer new and useful proteins with unprecedented control and accuracy. Our team has been behind breakthroughs in AI protein design for the past 7 years, including the first experimental validation of AI-generated proteins and diffusion models for protein structure and sequence.

Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.

We’re on a mission to leverage AI and voice technology to solve inefficiencies and revenue leakage in our healthcare system. With the rise of EHRs, the manual documentation burden on doctors has never been higher, leading to burnout and fatigue and high attrition rates. Assigning the correct diagnosis and billing codes is crucial for proper reimbursement and patient care, but medical coding is becoming more and more complex each year with growing numbers of codes (over 145,000 now), and doctors are unsupported by current technology to keep up with its ever increasing requirements. $125 billion is left on the table each year by healthcare organizations due to improper documentation and coding. Knowtex creates visit notes with up-to-date and accurate reimbursement codes from doctor-patient conversations, allowing the doctor to focus on patient care and preventing revenue leakage for hospital systems through standardized, transparent, and accurate documentation.

Malama offers doula-led holistic support during and after pregnancy at no cost to patients. Malama is in-network with Aetna, UnitedHealthcare, Anthem, Kaiser, and several Medicaid Managed Care Plans. Malama is backed by the Stanford d.school, Y Combinator (S22), Alpine Investors and more.

Turning therapy admin chaos into automated calm—VoiceAI for intakes, seamless prior auths, referral and scheduling management. Built by practice owners, for practice owners (www.getsolum.com).

Delfino AI helps automate the repetitive phone calls that providers' offices make to payors

Quinn makes the highest-stakes scientific decisions in drug development. Which drugs to bet on, what to develop next, how to get them to patients. In days instead of months.

Metriport provides real-time access to comprehensive medical data for 300M+ individuals across the US. Our open-source intelligence platform helps organizations access, analyze, and exchange patient data while integrating with all major healthcare IT systems. If you’ve been to doctors in the US, you may have encountered the problem: how does a healthcare provider get access to your up-to-date medical history to treat you properly? Reliance on archaic methods is still the norm: typically, you or your provider need to call the facilities where you’ve previously received treatment (assuming you remember them all), just to have them send your records via fax (yep, fax). This can take weeks, only then to have a provider sift through hundreds of pages of unstructured docs, just to figure out basic things like your active medication list, what conditions you may have, latest lab results, etc. This not only delays care—it can cause improper treatment, since the medical history is critical for informing treatment decisions. Metriport integrates fragmented medical data from thousands of sources—including both national and state/regional Health Information Exchanges (HIEs), ADTs, EHRs, pharmacies, and labs—through a single API connector. The platform then standardizes, deduplicates, and enriches this data to create a comprehensive longitudinal patient record, with AI-powered clinical summaries. Along with a rich understanding of patient health history, healthcare providers also get realtime updates about their patients' health through Metriport. This includes getting notified when a patient is discharged from the hospital, picks up their prescription from the pharmacy, or has a new lab result available. Through this data, care teams get insights across their patient population, helping with 30-day readmissions prediction, care gap closure, risk adjustment, and more. On top of all of this, Metriport enables healthcare organizations to share net-new clinical information back to all major healthcare IT systems, and to become interoperable with popular EHR systems such as Epic, Cerner, athena, eClinicalWorks, and many more—forming an internet for healthcare data. Metriport improves both patient and provider lives at the point-of-care, supporting use cases such as medication adherence, transitions of care management, chart prep, and much more. If you want to do work that matters, get in touch with us today.