Machine Learning Startups funded by Y Combinator (YC) in the San Francisco Bay Area that are currently hiring 2025

Scale accelerates the development of AI within organizations of any size to deliver critical business insights and operational efficiency. Its data-centric infrastructure platform leverages RLHF (Reinforced Learning with Human Feedback) to help organizations build the strongest AI models that supercharge their business, with customers across industries including Meta, Microsoft, U.S. Army, DoD’s Defense Innovation Unit, Open AI, General Motors, Toyota Research Institute, Brex, Instacart and Flexport.

At AgileMD, we are building the most advanced real-time predictive analytics and clinical algorithms platform for hospitals. Our cloud-based engine helps thousands of doctors and nurses around the country make medical decisions, so that every patient receives the highest quality and value of care based on the latest medical knowledge and data.

Healthcare needs good data. At PicnicHealth, we are building deep real-world datasets fueling cutting-edge research while giving patients control of their own medical record data. These complete, clinically-rich datasets produce unique insights — across dozens of diseases — to ultimately get the right treatments into patients’ hands faster. We work directly with patients and leverage state of the art machine learning to transform messy medical records into structured, research-ready datasets. To date we’ve helped tens of thousands of patients securely access their records and proactively contribute to advancing research in diseases that impacts their lives.

SmartSpot is a post Series-A stealth startup backed by Founders Fund and Khosla Ventures that uses computer vision to deliver an unparalleled fitness training experience to your home. Our unique hardware solution gives amazing trainers the ability to see their class participants in real time and deliver detailed advice that was previously only possible in person.

Proven is a data powered skincare company that creates personalized skincare products based on more than 47 factors about an individual's skin, genetic background, lifestyle and environment. Our formulations are rooted in the largest beauty database in the world, the proprietary Skin Genome Project, built in-house by Proven's cofounder Amy Yuan, a computational physicist from Stanford. The database has won MIT's AI Technology of the Year award and encompasses more than 20Million consumer datapoints and thousands of scientific articles on skin. Our challenge now is to tell the story of Proven, and share our industry leading personalized skincare products with the world.

Klarity is Enterprise AI that automates accounting and compliance processes for companies like DoorDash, CrowdStrike and Zoom. Klarity has two core capabilities: (1) understand documents like Orders, Invoices and Contracts to the same degree as a human, and (2) automate the following process - identifying outliers, matching, calculations and validations. Klarity reduces OpEx, delivers real-time turnaround and boosts accuracy.

Sapling offers an API and SDK to help businesses integrate language models into their applications. Its messaging assistant sits on top of CRMs and messaging platforms to help users more efficiently compose responses.

Short Story is a style discovery platform to help petite women find clothes that fit. The average American woman is 5'4" and petite, yet this remains an enormously underserved segment. We’re a team of curators passionate about finding style, quality, and fit for petite women. Our mission is to remove the “ugh” from the shopping equation and support petite women in telling their stories, stylishly and confidently.

Accept and reconcile B2B payments seamlessly.

Mach9 is at the forefront of leveraging advanced machine learning and computer vision techniques to transform geospatial data into actionable insights for urban development and infrastructure management. Our cutting-edge technology automates the detection and analysis of key urban features, aiding in the planning and maintenance of transportation networks.

We build software to manage, analyze, and optimize bioprocessing data. Our initial customers are bio-industrial companies, who produce various products in bioreactors.

At Phiar, we are building the first AI-powered AR navigation driving software solution that runs on a smartphone and in-vehicle displays, utilizing our ultra-lightweight road understanding AI that runs completely at-the-edge, in real-time, all on just a smartphone-level compute. Our mission is to enhance driving safety, facilitate more intuitive wayfinding, and connect drivers with their surrounding environments.