Machine Learning Startups funded by Y Combinator (YC) in the San Francisco Bay Area that are currently hiring 2025

Scale accelerates the development of AI within organizations of any size to deliver critical business insights and operational efficiency. Its data-centric infrastructure platform leverages RLHF (Reinforced Learning with Human Feedback) to help organizations build the strongest AI models that supercharge their business, with customers across industries including Meta, Microsoft, U.S. Army, DoD’s Defense Innovation Unit, Open AI, General Motors, Toyota Research Institute, Brex, Instacart and Flexport.

DeepAware builds an AI-driven automation system for GPU-intensive data centers. Our reinforcement-learning scheduler, real-time market integration, and unified dashboard slice energy waste by up to 30%. Coming soon: autonomous “robot-hand” inspections and maintenance to enable 24/7 operations with minimal staff. More info: https://deepawareai.com/ Jobs/Internship: https://www.deepawareai.com/careers

Theorem is training models that make program verification 10,000 times faster. Using verification as a feedback loop, developers have found zero-days in GPU accelerated code and cryptography implementations, and sped up code migration in legacy systems. If you have complicated code that needs to be correct and secure, sign up for our beta!

We are building state-of-the-art SLAM, perception, and spatial understanding models that leverage vision alone to map, interpret, and interact with the world.

Cloudglue APIs (https://cloudglue.dev) makes it easy to transform video and audio into structured data for your LLM/RAG/AI application. Our developer-friendly APIs makes it easy to integrate video chat into your AI assistant with minimal heavy-lifting.

At Anglera, we're developing a suite of AI agents to help e-commerce companies run their operations more efficiently. Our flagship agent helps our customers onboard, enrich, and manage their product data, reducing time per product from 15 mins down to 5 seconds. We previously developed ML to automatically enrich millions of products at Uber Eats, and we're now on a mission to automate the most common manual workflows for every e-commerce business.

At Undermind, we're building a search engine that can handle extremely complex questions. It’s geared at experts, like research scientists and doctors, who need to find very specific resources to solve high-stakes problems. We’ve rebuilt search from the ground up to address this. Our new approach employs high-quality LLMs to adaptively explore a database, mimicking how a human researcher carefully discovers information. This approach dramatically outperforms (by 10-50x) traditional keyword search and other modern AI-based retrieval methods. Our first target users are the 50 million researchers searching for scientific literature on PubMed and Google Scholar every month. We’ve have paying users across fields like medicine, ML, biotech, finance, and more.

Quantum computers will allow humanity to understand the world at its most fundamental level, enabling the acceleration of drug discovery and the development of new materials. Currently, quantum engineers spend days, sometimes weeks, manually getting their silicon chips to operational conditions to realize two qubits. A qubit is the information-carrying unit of a quantum computer, analogous to a bit in a classical computer. We need billions of qubits to make a useful quantum computer. Therefore, automation software will be vital to realizing this goal. Conductor Quantum will develop AI software to remove the human from the loop, enable the scaling of silicon quantum technology and build a silicon-based quantum computer.

Oway is an AI-driven freight platform that turns America’s empty truck space into a new category of freight shipping. Every year 50% of U.S. truck space goes unused, a $100B+ inefficiency. Oway uses AI to automatically price, match, and sell that space in real time, giving businesses freight shipping that is dramatically faster and cheaper than traditional options. We're building the largest decentralized network of America’s empty truck space - a transparent infrastructure layer any shipper, broker, or carrier can plug into. For shippers, this means freight costs that are up to 50% lower than traditional LTL (shipments from 1 to 12 pallets), along with faster delivery windows because freight moves directly from dock to dock without the slow handoffs, warehouses, or cross-docking infrastructure that LTL depends on. For carriers, Oway’s integration can increase annual revenues by up to 30% with minimal impact on existing schedules. They simply earn more by monetizing space that would have gone unused. Our mission is to transform empty truck space into an asset that strengthens U.S. competitiveness. By lowering the cost of goods sold, we help businesses grow. By improving carrier margins, we make trucking more sustainable. And by digitizing and decentralizing freight, we are laying the foundation for a resilient, transparent logistics layer that can support America’s reindustrialization in the decades ahead. Oway makes freight shipping as simple as ridesharing - click a button, book a truck, and move goods at the true cost of available capacity.

Cartage is the future of freight coordination. Transparent, tech-driven and eliminating the need for human coordinators.

Ocular AI is the data annotation engine for Generative AI, Computer Vision, and Enterprise AI models. We help you transform unstructured, multi-modal data into golden datasets to power generative AI, frontier models, and computer vision. Ocular Foundry is the most intuitive, data-centric, and fastest platform that lets you label, annotate, version, and deploy your data for training models. It also orchestrates your annotation jobs, improving collaboration with members and annotators. With Ocular Bolt, shift from humans in the loop to experts in the loop to supercharge your data labeling and annotation projects. Our global expert workforce ensures fast, accurate results—no matter the scale or complexity of your data. Companies spend huge amounts on training data, but Foundry and Bolt are AI-native tools that lower costs, reduce manual effort, and accelerate high-quality data collection. We’re replacing outdated, clunky, and expensive data software!

Safety from humans in the loop is a mirage. We evaluate, research, and apply AI control in our own real-world deployments of autonomous organizations. We are building the Safe Autonomous Organization. We iteratively launch and scale autonomous organizations, while bridging AI control research with real-world testing.

Casca is an AI-native platform transforming small business lending by enabling banks and lenders to originate 10x more loans with 90% less manual effort. Our solutions streamline the entire loan process—from customizable application forms and secure applicant portals to AI-powered assistants, automated document collection, KYB checks, and underwriting. We’ve found product market fit and are scaling our team very quickly. Small businesses are the heart of the American economy. Many banks shy away from providing funding because of the manual effort in pursuing those deals. With us, that changes. We unlock affordable, quick bank funding for the 30M+ small businesses in the US who would otherwise be subject to the high interest rates from predatory online lenders. We are a world-class team of banking & AI experts from Stanford, MIT & Y Combinator. We like to win and we know that the only thing between us and the title is our own ability to improve every day.

PropRise is building the AI operating system for commercial real estate investing. We automate the entire workflow from sourcing to closing: our AI finds deals nationwide that match your criteria, then populates your Excel models with extracted data in 90 minutes instead of 4 hours. CRE teams currently waste 80% of their time on manual tasks and miss profitable deals because they can't analyze fast enough. Major firms like Colliers and Public Storage already use us to analyze 7x more deals. We're creating the first end-to-end platform that acts as the system of autonomy, intelligence, and record for the $20 trillion CRE market.

Continue enables developers to ship faster with Continuous AI. The future of coding isn't writing more code. It's delegating the boring parts, so you can build the interesting stuff. Developers are drowning in AI-generated code. Continuous AI solves this by automating the workflows around code, not just the code itself. The role of the software engineer is shifting from prompting AI to designing processes that run automatically. With hundreds of thousands of users, Continue is loved by developers worldwide at organizations ranging from small startups to Fortune 500 companies. Continue has raised $5.1M from Heavybit, Y Combinator, and angel investors. The company was founded in 2023 and is based in San Francisco. We believe the time is now to create a future where developers are amplified, not automated.

We're building autonomous robots to make surgery safe, easier and more efficient. Robots currently perform about 1/4 of surgeries but only help with the physical aspects. We use AI to make surgery cognitively easier. This has far greater potential to improve outcomes and reduce costs. Founded by 3x founders from medtech and autonomous vehicles, we're on track to be the fastest surgical robot to market of all time. First indication is prostate enucleation.

Diffuse is building generative AI for protein design. Our mission is to build AI systems that engineer new and useful proteins with unprecedented control and accuracy. Our team has been behind breakthroughs in AI protein design for the past 7 years, including the first experimental validation of AI-generated proteins and diffusion models for protein structure and sequence.

1stCollab is the first influencer platform that fully automates and optimizes every aspect of your influencer marketing program. We’ve helped hundreds of startups launch their first campaigns and enabled larger brands to scale to thousands of influencers, while saving them over $1M annually in influencer spend. What we offer: - Smart search & recommendations – Instantly connect with thousands of relevant influencers. - Full campaign automation – From outreach and negotiations to contracts, payments, and taxes, we handle it all. - Real-time performance tracking – Monitor conversions, revenue, and run A/B tests with detailed reporting.

Cosine is a fully agentic SWE that allows you to instantly work on every single ticket at once, asynchronously.

Polymath is building a general autonomy stack for cautious vehicles. Our software allows any industrial vehicle - whether it's a tractor in a field or a bulldozer in a mine, drive itself. We bundle together AI, ML, Controls, ROS, Safety and best-in-class deployment practices to enable our customers to tell automated vehicles to do via a REST API. We're on more robots than we have engineers, are seeing our revenue (and robotic fleet) grow rapidly, and are looking for folks who want to help automate the world.

Delfino AI helps automate the repetitive phone calls that providers' offices make to payors

We build software to manage, analyze, and optimize bioprocessing data. Our initial customers are bio-industrial companies, who produce various products in bioreactors.

End-to-end privacy, security, and compliance solutions to prepare your organization for emerging AI regulations.

Mach9 is at the forefront of leveraging advanced machine learning and computer vision techniques to transform geospatial data into actionable insights for urban development and infrastructure management. Our cutting-edge technology automates the detection and analysis of key urban features, aiding in the planning and maintenance of transportation networks.

Accept and reconcile B2B payments seamlessly.

Openlayer is the governance platform for AI applications.

Roboflow enables developers to make the world programmable. Use our tools to build better datasets (collect image, video / annotate), models (foundation and fine tuned small models), and deployments (self hosted, edge, APIs, SDKs) for computer vision. Over 250k developers, including those from over half the Fortune 100, build with our open source and hosted tools. Build with us: https://app.roboflow.com Hack with us: https://roboflow.slab.com/public/posts/roboflow-hackathons-external-u478m1iz Work with us: roboflow.com/careers

TRM is on a mission to build a safer financial system for billions of people. We deliver a blockchain intelligence data platform to financial institutions, crypto companies, and governments to fight cryptocurrency fraud and financial crime. We consider our business — and our profit — as a way to move towards our mission sustainably and at scale. Join our mission ➔ www.trmlabs.com/careers

Short Story is a style discovery platform to help petite women find clothes that fit. The average American woman is 5'4" and petite, yet this remains an enormously underserved segment. We’re a team of curators passionate about finding style, quality, and fit for petite women. Our mission is to remove the “ugh” from the shopping equation and support petite women in telling their stories, stylishly and confidently.

Sapling offers an API and SDK to help businesses integrate language models into their applications. Its messaging assistant sits on top of CRMs and messaging platforms to help users more efficiently compose responses.

Klarity is Enterprise AI that helps companies like OpenAI, DoorDash, CrowdStrike and Zoom bend the G&A curve. Klarity delivers two core capabilities: (1) unlimited transformation; creating a digital twin of your business to identify gaps, risks and inefficiencies, and provide valuable insights into your business in weeks instead of quarters, and (2) intelligent document processing that turns contracts, invoices, and POs into audit-ready data with 82%+ pass-through rates. Klarity reduces OpEx, boosts accuracy, and empowers CFOs to deliver board-ready ROI.

Proven is a data powered skincare company that creates personalized skincare products based on more than 47 factors about an individual's skin, genetic background, lifestyle and environment. Our formulations are rooted in the largest beauty database in the world, the proprietary Skin Genome Project, built in-house by Proven's cofounder Amy Yuan, a computational physicist from Stanford. The database has won MIT's AI Technology of the Year award and encompasses more than 20Million consumer datapoints and thousands of scientific articles on skin. Our challenge now is to tell the story of Proven, and share our industry leading personalized skincare products with the world.

SmartSpot is a post Series-A stealth startup backed by Founders Fund and Khosla Ventures that uses computer vision to deliver an unparalleled fitness training experience to your home. Our unique hardware solution gives amazing trainers the ability to see their class participants in real time and deliver detailed advice that was previously only possible in person.

Healthcare needs good data. At PicnicHealth, we are building deep real-world datasets fueling cutting-edge research while giving patients control of their own medical record data. These complete, clinically-rich datasets produce unique insights — across dozens of diseases — to ultimately get the right treatments into patients’ hands faster. We work directly with patients and leverage state of the art machine learning to transform messy medical records into structured, research-ready datasets. To date we’ve helped tens of thousands of patients securely access their records and proactively contribute to advancing research in diseases that impacts their lives.

At AgileMD, we are building the most advanced real-time predictive analytics and clinical algorithms platform for hospitals. Our cloud-based engine helps thousands of doctors and nurses around the country make medical decisions, so that every patient receives the highest quality and value of care based on the latest medical knowledge and data.

At Phiar, we are building the first AI-powered AR navigation driving software solution that runs on a smartphone and in-vehicle displays, utilizing our ultra-lightweight road understanding AI that runs completely at-the-edge, in real-time, all on just a smartphone-level compute. Our mission is to enhance driving safety, facilitate more intuitive wayfinding, and connect drivers with their surrounding environments.