Healthcare Startups funded by Y Combinator (YC) in New York 2026

Overdrive Health offers AI powered medical billing services, helping providers get paid more money in less time. Our technology enables us to provide the best quality insurance and patient billing services for a fraction of the usual cost

We deliver high-quality, cost-effective healthcare to employees through text. Employers cut 10–20% of healthcare spend. Employees get concierge care that improves outcomes. Our AI agents analyze clinical data to identify care needs. We treat common conditions through our integrated virtual clinic. For more complex care, our agents find the best in-network providers using millions of price and quality data points, and handle end-to-end appointment booking.

Nori is a concierge-level AI health coach in your pocket. It takes all of your health data—Apple Health, medical records, wearables, everything—and boils it down into a personalized daily plan. Users love it: “It's truly one of the best apps and I check it first every day. Since using Nori, I've been limiting devices in bed and eating earlier—and I'll be damned if it's not working... I started getting more deep sleep, my resting HR dropped to 43, my recovery improved.”—Jen, Nori user"

Locata is an AI referral management platform for Primary Care. We deploy AI agents to automate every step of the referral process that back-office staff face daily, from submitting prior authorizations to broadcasting updates and following up with patients. This frees up staff to focus on patient care. Primary care back-offices are severely understaffed and overburdened by administrative work associated with referrals. Additionally, patients suffer navigating the complex referral process, which can have disastrous health effects if they don’t get the care they need. These factors point to a glaring gap in the system—where out of over 100 million specialist referrals issued annually in the US, only half are actually completed. Locata is tackling this problem head-on, saving administrative staff hours each week and ensuring that the referral process goes as smoothly as possible for patients and their providers. Alejandro and Josh met at Stanford where they graduated with BS degrees in Computer Science. Alejandro was a senior software engineer at Meta’s Reality Labs where he led development of several AI features for wearable products and prior to that conducted AI research at Stanford Medicine. Josh graduated with a masters in Computer Science, specializing in AI, before working as a software engineer at Google where he developed AI products that served over 1 billion users. Within two weeks of building our product, we signed a major regional health center and have saved them over 100 hours of work in our first month live.

CareSwift is a real-time AI assistant built directly into ambulance reporting systems, guiding medics as they document care and instantly flagging errors. Crews complete accurate, compliant reports in under three minutes, cutting documentation time by 80 percent and helping agencies avoid insurance claim denials. Ambulance crews lose valuable time completing reports after each call. Even minor mistakes cause insurance claims to be rejected.

Trapeze empowers doctors to answer patient calls 24/7 with our voice agents clones of their best call center reps and receptionists. In the past 3 months, we’ve onboarded 140+ doctors nationwide serving 1,000,000+ patients. We're building the AI-native Zocdoc to create the standard for how patients and providers find each other. Follow along on the BTS of our journey: https://www.tiktok.com/t/ZTjQyxEQx/

Post-acute care loses billions to broken revenue infrastructure. Claim Health prevents it. We catch denials before they happen, automate the work drowning ops teams, and connect every step from referral to cash so agencies can scale without adding headcount. Kevin and JJ bring nearly a decade of experience building and scaling healthtech companies across different segments. Post-acute care is a $400B market with over $20B in annual revenue leakage due to broken revenue infrastructure. Claim Health is fixing that.

Asha Health is building the future of self-learning generative AI for healthcare.

We're building Matcha, the faster, smarter way to hire clinical talent—helping hospitals find active, qualified candidates at a fraction of the time and cost of job boards or headhunters. Matcha engages candidates at scale, matching them to your organization by qualifications and cultural fit. Recruiters save time, hospitals save money, and candidates get a better experience—a radically better hiring model for everyone involved.

Codes automates patient record collection. Today, documents are scattered across EHRs, providers, and faxes; we use AI to compile & analyze docs for those who need them.

ACX is developing a new standard for precision agriculture technologies by providing sustainable, eco-friendly alternatives to chemical pesticides. Our mission is to transform agriculture through sustainable biological crop protection that increases yields while safeguarding the environment, farmers, and consumers.

The American healthcare system is complicated. 88% of US adults cite difficulties navigating the healthcare system. The good news is patient advocacy became a covered benefit by Medicare in 2024. Understood Care matches Medicare patients with a healthcare personal assistant (known as a Patient Advocate) at little to no cost to the patient. Patient Advocates help patients patients access care - finding resources, helping fill out paperwork, and much more. Understood Care uses AI and healthcare expertise to deliver the highest quality patient advocacy to the 68 million Medicare patients in the US.

Clarion is building the most advanced AI communication layer for healthcare. Our AI agents handle the overwhelming volume of calls and messages that clinics face daily—from scheduling to billing to prescription refills—freeing staff to focus on patient care. We're an in-person company based in New York. Today, clinics miss 30-40% of inbound calls due to staffing shortages. We're solving this by automating complex workflows end-to-end, already serving tens of thousands of patients monthly across virtual care companies, health systems, and a $5B health insurance company. We've raised $5.4M from Accel, Y Combinator, Sequoia (scout), and healthcare founders from Ophelia, Medallion, and Counsel Health. Our founders bring both clinical and technical expertise—our CEO Ryan is a Stanford/Harvard-trained physician who was on the founding teams of Two Chairs and Ophelia, while our CTO Jeffrey built voice AI at Amazon Alexa and led AI/ML teams at Salesforce. Join us as we transform healthcare communication—creating a future where patients get faster resolutions and providers reclaim time for what matters most.

Understand & control neural syntax.

Fortuna is a one-stop solution that helps consumers navigate Medicaid end-to-end from eligibility and enrollment to renewing coverage. Our platform creates value as the middleware layer for the $800B Medicaid ecosystem.

Don't die of heart disease. While heart disease is the #1 killer worldwide, 80% of heart disease is preventable. Empirical's program starts with an advanced lab test with 100+ biomarkers, including ApoB, Lp(a), inflammation, and more. Then, we help you model your lifetime risk of heart disease and generate a plan to reduce your risk to an optimal level. Then we help you achieve that plan. Empirical is licensed, registered, and insured to deliver real medical care in 30+ US states covering 200m+ people. We're growing >25% monthly.

Simbie AI voice agents are EHR-integrated and answer SMB medical practices' phones and call their patients for them. They handle both admin (scheduling) and clinical (results) tasks. Simbie is powering the return to independent medicine—50% of care delivered today—as doctors and patients badly want. After years of healthcare consolidation that left patients worse off and physician burnout surging, we're giving SMB the (infinite) scale to compete with hospitals, without the overhead.

Sohar Health is an AI-driven front-end RCM solution that transforms insurance verification processes for healthcare providers, enabling faster patient conversions and reducing administrative workloads. With a 95% automation rate, our API-first platform seamlessly integrates into existing workflows to provide real-time claim accuracy and eligibility checks. Key performance metrics showcase the power of our technology: Median latency of just 6 seconds, ensuring real-time eligibility; over 90% of checks returned within 30 seconds for increased patient conversion; 96% accuracy in identifying and verifying benefits details; Industry-leading 99% accuracy for eligibility determination; >90% carve-out detection rate, mitigating surprise billing risks; a 60% success rate with our Insurance Discovery API, helping identify coverage for self-pay patients. Our customers include outpatient clinics, specialty practices, and digital health platforms looking to streamline front-end claim management. By reducing errors and maximizing clean claim submissions, Sohar Health empowers healthcare organizations to convert and retain more patients, reduce operating costs, and increase their top-line revenue.

MICSI is introducing AI software that doubles resolution and halves scan time. This breakthrough enables imaging centers to significantly enhance their capacity and patient throughput, potentially saving countless lives and generating an additional $2 million of revenue per MRI scanner. Our initial offering serves as a stepping stone toward the company’s larger vision of transforming the MRI into a truly quantitative instrument that is capable of providing highly reproducible data for more accurate diagnoses and patient management.

SelectIQ addresses the primary bottleneck in drug development: recruiting patients into clinical trials. We analyze electronic health records to help doctors find clinical trials for their patients, and to help trial sites find patients for their studies. 72% of doctors want to inform their patients of clinical trials, but only 5% do. We're on a mission to close that gap, ultimately bringing safer, more effective drugs to the patients who need them.

Loula is a software platform and national provider network for independent birth & postpartum doulas to boost their practices by accepting health insurance. Doulas typically operate outside of the traditional healthcare system and face an enormous learning curve and administrative burden when trying to accept insurance. This is why we created Loula. Starting with doulas in California, Loula handles their credentialing, contracting, and revenue cycle management so that they can focus on delivering the best quality care to their clients.

Nephrogen is a biotech company developing curative gene therapies for kidney and pancreatic diseases. Kidney disease affects 1 in 7 Americans (~50 million people), has no cure, and accounts for nearly 10% of the Medicare budget.

Serinus Biosciences is tackling one of the toughest problems in cancer treatment: creating combination therapies to override treatment resistance. We leverage cutting edge technology to design a fully explainable AI platform primed with decades of system biology knowledge. Uniquely powered for biological inference, our AI engine uncovers how cancer cells evolve treatment resistance and identifies molecules to overcome resistance escape routes. We design combinations that are safer, more effective, and can get to patients quickly. Founded by MIT PhDs and supported by a scientific advisory board of top academics from the Broad Institute, Dana-Farber, and UCSD, Serinus is powered by Y Combinator and other top investors to revolutionize precision medicine.

Isabl has developed software that can analyze the entire genome of cancer patients. Today, when people get cancer, they get a genetic test of their tumor that analyzes only a few possible mutations. With Isabl, you run the tumor through an Illumina sequencer and get the whole genome, then our software is able to analyze all the mutations. Our breakthrough technology provides unprecedented clarity into tumor biology to aid treatment planning. This opens up opportunities for precision diagnostics, disease surveillance and biomarker discovery.

Nourish is solving America's healthcare crisis by helping people eat better. We connect chronic condition patients with a Registered Dietitian via telehealth and get it covered by their health insurance.

We are a drug discovery company developing a new generation of therapeutics that embrace the complexity of disease. Currently available approaches for creating drugs work on the principle of finding one drug-one protein 'magic bullets'. However, diseases such as cancer and autoimmunity are often the result of several dysregulated proteins across many distinct biological pathways. We are building a computational-experimental platform to design therapeutics that can target several disease-causing proteins at once. By designing multi-specific drugs, we are able to create therapeutics that are more efficacious and safer than existing medicines.

Nest is a lab-agnostic, comprehensive solution for organizations to launch and implement large-scale genomic programs. The platform includes the ability to triage, consent, and counsel patients for genetic testing, provide EMR-integrated clinical decision support for providers managing patients with genetic results, and manage patients’ clinical needs across the continuum of care.

Craniometrix has raised over $21 million to help make dementia suck less. Dementia is tough – but it can be easier. Turns out, if you give families the right non-clinical coaching and support, you can avoid 30% of hospitalizations for these patients. And Medicare has recently started paying for that coaching. We launched our care navigation service for dementia patients in July of 2025, hit $4M of ARR, and just raised a $15M Series A. We leverage AI to provide best-in-class care, alleviating the burden on providers. Come help us build!

BBy's condensing device turns milk into a fine powder that spares the biome leaving it biologically and immunologically active. This allows hospitals to stop wasting precious nursing time defrosting milk for hours and milk wastage from discarding rules. Simply weigh the powder, add water, shake and serve. No more freezing, no more defrosting, only patient care. NICUs are time sensitive wards in the hospital, time is everything and yet nurses today continue to prepare frozen milk for infants in what's known as the milk shift. A shift where the nurse spends the day defrosting milk for the next shift of nurses. Our tech is now fully peer reviewed and published, yielding safe and reliable results in over 20 hospitals in the New York Tri-State. The company is headed by Vansh Langer MD, a physician (Windsor University, University of Chicago) and Blanca Aguilar Uscanga PhD, a Bioengineering/Food Science PhD (University of Guadalajara /Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI)) team that has over 50 published works in the field between them and are experts in the science of infant nutrition. Vansh saw the immense need for a time critical solution in the NICU and helped solve the puzzle with Dra. Blanca and her team and decided to work together to: Nurture the Future.

Instalab gives you direct access to all the preventative tests you need to do this year to stay on top of your health. Trusted by tens of thousands of top-performing founders, executives, and professional athletes.

Automate and scale post-discharge follow-up calls with AI coordinators that specialize in transition of care.

Output Biosciences is pioneering Biologically-Aware Generative AI to finally understand complex biological systems. Our new generative AI architecture can handle the extremely long, nonlinear, fragmented, and high dimensional data of biological systems. We are building Large Biological Models that can generate breakthrough medicines and transform the way we diagnose, treat and prevent disease.

Humane Genomics has developed a platform to engineer cancer killing viruses. We have taken a first principles approach to design and make oncolytic viral therapies. Using a highly lytic RNA virus engineered with "2 factor authentication" (using selective infection and selective replication) they have an on-target to off-target kill ratio > 1000. We are working on our first indication, pediatric liver cancer (hepatoblastoma), with our partners at Texas Children's Hospital, who are world leading experts. We have in vivo (mouse) data showing safety and currently developing efficacy data and are showing 50% reduction in tumor volume.

SFA Therapeutics is creating therapeutically-tailored oral drugs that regulate the immune system; with a focus on autoimmune diseases and cancers that originate from chronic inflammation. There are over 300 million patients who suffer from autoimmune diseases. Our treatment is designed to block the root cause of many of these chronic inflammatory diseases, with safe oral drugs. We have strong clinical data from a phase 1b clinical trial in psoriasis, and human data in pancreatic cancer, uveitis and NASH. we have a total of 9 drugs in our pipeline and 15 patents.

Measured is a telemedicine platform helping people with chronic conditions get access to affordable care. We're growing rapidly and have thousands of customers across the US.

Wyndly (https://www.wyndly.com) fixes allergies by training patients' bodies to ignore their allergy triggers. Frustrated allergy suffers come to us when they no longer want to deal with pills and sprays. We diagnose the patient’s unique allergy profile and create a personalized treatment plan to give the patient lifelong allergy relief. Specifically, Wyndly is increasing access to sublingual immunotherapy (SLIT) for allergy care. For our patients, we're combining the convenience of telehealth and direct-to-consumer care with an exceptional patient experience that never loses the context of care. Wyndly represents an opportunity to change allergy care forever. With 60 million Americans suffering from allergies today, and with this number doubling over the coming years, there's simply an incredible need for the convenient care Wyndly provides. You can read more about us in [Techcrunch](https://techcrunch.com/2021/02/12/wyndly-aims-to-bring-allergy-drops-to-the-masses/). The Wyndly Model At Wyndly, we believe that better connections lead to better care, and we’re committed to making both happen at every step of the patient journey. Our allergy practice allows our patients to work with expert providers to develop personalized treatment plans for long-term allergy relief using clinically proven therapies. From a patient’s initial consultation to their final treatment delivery, we want the Wyndly experience to be a breath of fresh air for allergy sufferers – truly effective allergy relief, simply and efficiently delivered. Once we've conquered allergies, we're transforming the care model for every chronic condition. While transactional care for purchasing pills has flourished in telehealth, no one has gone after chronic care. Patients with chronic conditions are shuffled between providers, insurance, and more -- and they never feel heard. These patients deserve better, and we're going to give it to them. Wyndly is starting with allergies, but we'll expand into asthma, sleep apnea, and other conditions in the near future. Our values **Compassion**: We approach all our patients and partners with an open mind and a genuine desire to be of service. **Focus**: We do a few things very well, and are always clear about our boundaries and direction of travel. **Courage**: We embrace ambiguity and discomfort because we know that’s how we grow. **Progress**: We make something better every single day. *It boils down to empathy and forward momentum in everything we do.* The team Wyndly is proudly backed by Y Combinator and a leading group of angel investors and VCs. The founders are Dr. Manan Shah (Chief Medical Officer), an ear-nose-and-throat surgeon who’s a leading practitioner of telehealth in his specialty, and his cousin Aakash Shah (CEO), who led growth engineering at SparkGift (acquired by Stockpile in 2016) and Parse.ly (acquired by Automattic in 2021).

We’re on a mission to make behavioral health more available and accessible. We're backed by a16z, YCombinator, Craft, and many others to make this dream a reality. At Camber, we build software for clinicians to improve quality of care. We streamline and replace manual efforts so clinicians can focus on what they do best: providing high-quality care. — Healthcare is broken. We think this is a problem worth solving, and we think we know how to solve it. Interested? Check out https://jobs.ashbyhq.com/camber.

CoreCare is the leading AI-powered workflow platform helping Post-Acute and Long-Term Care (PALTC) providers achieve operational excellence. Trusted by 1,000+ locations nationwide, CoreCare increases admissions, optimizes reimbursement rates, improves collection metrics, and reduces administrative burdens—all on one intuitive platform. At the heart of CoreCare is Collaborative Revenue Management, which unites essential data and teams on a shared platform. Our approach empowers employees—regardless of skill or tenure—to perform like experts from day one, collaborate with their peers on critical work, and give management unmatched visibility into performance across the organization. CoreCare replaces error-prone spreadsheets and fragmented portals with streamlined workflows that drive measurable results. Trusted by leading providers, CoreCare redefines how teams work and sets a new standard for AI in long-term care.

Gilgamesh is a pioneering, clinical stage mental health science-focused biotechnology company. We have a disciplined focus on developing innovative new chemical entities (NCEs) leveraging a unique combination of medicinal chemistry, intellectual property strategy, neuroscience & neurobiology, and drug development expertise. We are an experienced team, with proven success in biotech exits and inventions.

Liyfe remote symptom management platform utilizes Artificial Intelligence (AI) to automate oncology nurse triage pathways and high-risk patient detection. It helps you standardize procedures, streamline existing clinical protocols, reduced ER visits and hospitalizations.

Kingdom creates and sells Superculture® ingredients. Our Superculture® ingredients are an entirely new class of clinically-validated postbiotics that target the root causes of unmet pet health needs. Superculture® Pet Oral and Superculture® Pet Immune are our first two breakthrough ingredients, driving industry-leading efficacy and unlocking new marketing claims for brands.

If you're a YC company: Book Here! https://calendly.com/danielle-wimberly-vitablehealth/30min We are a team of engineers, clinicians, and operators rethinking healthcare for startups and and SMB's. We make it simple for startups to offer ICHRA with built in direct primary care, including free virtual visits, over 1,000 prescriptions, and 40+ lab tests. Contributions are made with tax-free dollars, and we handle everything from onboarding to ongoing care so founders can stay focused on building. We are backed by world class investors like First Round Capital, Cherryrock, Y Combinator, and SoftBank, along with incredible founders and operators including Michael Seibel (YC, Twitch), Immad Akhund (Mercury), Allison Pickens (Gainsight), Jack Altman (Lattice), Dan Folkman (GoPuff), and others.

Ophelia helps people quit opioids without going to rehab. We offer online doctor’s visits, withdrawal medication prescriptions, and support for long-term recovery, using a protocol 6x more effective than most rehabs (2/3rds of which don't have doctors). More than 3 million Americans are addicted to opioids, but 80% are not getting help, due to jobs, families, and privacy concerns. Meanwhile, there's a proven treatment that increases survival rates by 600%, and it's low cost, discreet, and convenient. It's called MAT, and it looks like treatment for anxiety or depression: medication plus therapy. However, doctors need a special waiver to prescribe the medication, which fewer than 5% of them have, so it's difficult to get, and most people are buying it on the street. Sadly, drug dealers aren't doctors: every 11 minutes another American dies of an opioid overdose, now the #1 cause of death for Americans under 50. Ophelia is replacing rehab with telemedicine, using proven science and a consumer-first approach. The opioid treatment market in the U.S. is $15B, and 85% of opioid addicts have insurance that pays for it. We're treating roughly 400 patients with thousands more waiting. Zack started Ophelia after losing his girlfriend to an opioid overdose, who found it easier to get medication from a drug dealer than a doctor. We are raising money to help patients in waiting, grow our footprint, save lives, and earn venture-level returns for investors.

H1 helps connect the healthcare ecosystem by providing a global platform of every healthcare professional and healthcare organization.

We connect healthcare workers (physicians, advanced practitioners, nurses and allied health workers) to hospitals/clinics/telehealth companies for short/full time job opportunities.

**TL;DR:** Legacy (YC S19) is a startup focused on the fast-growing field of fertility and family planning. Founded at Harvard, the company has now raised $40M from leading investors like FirstMark Capital, Bain Capital Ventures, Section 32, Tribe Capital, and even celebrities like Justin Bieber, The Weeknd, and others. **What we're doing** We aim to change the outdated view that fertility is a "women's issue" by creating an accessible, affordable product for men & people with sperm. This includes everything from a mail-in kit for sperm testing & sperm freezing, personalized sperm improvement products, tele-health, DNA fragmentation analysis, supplements, and more. **Why are we the leader?** The company was founded at Harvard by a team of healthcare and fertility experts. We obsess about talent density and have out-executed our competitors over the past few years. Beyond our D2C channel, we've also unlocked: 1. Nationwide insurance coverage (10M+ lives) 2. Military contracts (Including the Navy SEALs and 15M+ veterans) 3. Employer offerings (Working with the top fertility benefit providers) **Tell me about the team** We're a team of about 30, extremely diverse (majority female, majority immigrants, strong LGBQTIA+ representation, age range of 25-65), and very values driven. Our 5 values are customer centricity, reliability, kindness, openness, and winning. Learn more about our values here: https://khaled-legacy.medium.com/legacys-values-and-why-they-matter-db116539d3da Learn more about our workplace here: https://khaled-legacy.medium.com/how-and-why-legacy-is-reinventing-workplace-benefits-9e5fda6cb863 Read about our mission to humanize the path to parenthood: https://khaled-legacy.medium.com/how-and-why-legacy-is-reinventing-workplace-benefits-9e5fda6cb863 Learn more about sperm and why it matters here: docsend.com/view/zkgk7ws

As healthcare costs have increased, the patient's home has become incredibly important as a site of care. Yet, patients recovering at home are highly underserved. Patients can only get better at home if they receive the high-quality care that they need reliably. The existing in-home care process involves patchwork of different vendors, all connected through faxes by nurses. We're building modern, robust software that solves this challenge and brings this market online.

We provides tools, data and systems to facilitate real-time insights, decluttering outbreak detection and enhancing risk mitigation. Our surveillance is used by industry, public heath and consumers globally.

C16 Biosciences is decarbonizing consumer products supply chains by producing next-generation ingredients. The company's biomanufacturing platform produces better performing, more sustainable alternatives to oils and fats, and their first product is an alternative to palm oil. The company owns and operates Palmless™ alternative fats and oils.